Which landmark is notable for its historical significance in Manhattan?

The Empire State Building is widely recognized for its historical significance in Manhattan due to its status as a symbol of American industrialization and urban growth during the 20th century. Completed in 1931, it was the tallest building in the world until the completion of the North Tower of the World Trade Center in 1975. It represents the art deco architectural style and was a testament to the ambitious spirit of the era, built during the Great Depression. The building is not only a major tourist attraction but also an enduring icon of New York City's skyline and has played a significant role in American pop culture, appearing in numerous films and media.

While the others listed also hold considerable significance, the Empire State Building stands out for its historical context relating to economic progress and urban development in New York City during a challenging period in history.